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Notre Dame vs. Ohio State Odds, Prediction: 2025 CFP National Championship Game Picked by an Expert Age 58-37

The No. 7 seed Notre Dame Fighting Irish and the No. 8 seed Ohio State Buckeyes will compete in the College Football Playoff National Championship Game on Monday. Notre Dame opened the playoffs with wins over Indiana and Georgia before sneaking past Penn State in the Orange Bowl on January 9. Ohio State suffered a disastrous loss to Michigan in the regular season finale, but responded with double-digit playoff wins. Over Tennessee, Oregon and Texas. These teams met in 2022 and 2023, with Ohio State winning both games.

The game is scheduled to kick off from Mercedes-Benz Stadium in Atlanta at 7:30 PM ET. The Buckeyes are 8.5-point favorites in the latest Notre Dame vs. Ohio State via SportsLine consensus, while the over/under for total points scored is 45.5. Ohio State is at 27.5 points overall, while Notre Dame is at 17.5 points. Before making any choice between Notre Dame and Ohio State, Check out college football predictions from SportsLine Notre Dame expert Mike Tierney.

A veteran sportswriter and handicapper whose work regularly appears in the New York Times and Los Angeles Times, Mike Tierney is 58-37 in his last 95 college football betting picks, returning $1,689 to $100 players. Additionally, he is 13-5 in his last 18 team picks in matchups that include Notre Dame, returning nearly $800. Anyone who follows him on sportsbooks or betting apps could be on his way to moving up.

Now, Tierney has his sights set Notre Dame vs. Ohio State. You can Visit SportsLine now to see his picks. Here are the FBS college football lines and trends for Notre Dame vs. Ohio State:

  • Spread of Notre Dame vs. Ohio State: Ohio State -8.5
  • Notre Dame vs. Ohio State Over/Under: 45.5 points
  • Notre Dame vs. Ohio State line: Ohio State -389, Notre Dame +305
  • Ohio State University: The Buckeyes are 4-1 in their last five games
  • ND: The Fighting Irish are 10-0 ATS in their last 10 games
  • Notre Dame vs. Ohio State picks: See the picks at SportsLine
  • Notre Dame vs. Ohio State stream: FuboTV (Try for free)

Why could you cover Ohio

Ohio State was perhaps the most impressive team in the College Football Playoff, winning its first two games in comfortable fashion and then finding a big play late against Texas to pull away in that game. Senior quarterback Will Howard had 289 passing yards and a touchdown against the Longhorns, headlined by a 75-yard screen pass to running back TreVeyon Henderson just before halftime. Jack Sawyer’s late scoop from 83 yards out and slammed the door on that one.

The Buckeyes have an explosive and balanced attack that averages 35.8 points per game. Howard completed 72.6% of his passes for 3,779 yards and 33 touchdowns, while Henderson and Quinchon Judkins each racked up more than 950 yards. Ohio State has covered the margin in four of its last five games, and is 4-1-1 ATS in its last six against Notre Dame. Find out which team you will choose here.

Why could you cover Notre Dame?

While the Buckeyes have been the most dominant team in the CFP, Notre Dame has been the most profitable team in college football since the start of the season. The Fighting Irish have covered the spread in 10 straight games, including all three of their playoff games. They beat Georgia by 13 points in the quarterfinals, as quarterback Riley Leonard had 90-yard and 80-yard runs.

Leonard had 223 yards and a touchdown in the semifinals, helping Notre Dame advance to the title game with a 27-24 win over Penn State. Sophomore wide receiver Jaden Greathouse had his biggest game of the season, catching seven passes for 105 yards and a score. The Fighting Irish are 7-0-1 ATS in their last eight games against Big Ten opponents. Find out which team you will choose here.

How to pick Notre Dame vs. Ohio State

Tierney analyzed Ohio State vs. Notre Dame from every possible angle. He tends to score and has also discovered the X-factor that has him jumping to one side of the space. Find out what it is, and Which team to support, at SportsLine.

So who will win Notre Dame’s game against Ohio State on Monday, and what will be the deciding factor that makes one side of the lead hurt so badly? Visit SportsLine now to see which side Ohio State vs. Notre Dame running back is on, all from the expert who’s an incredible 58-37 in his college football picks, returning over $1,600 for 100 players.

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